5 Facts you should know about

Generalized pustular psoriasis

Key symptoms of GPP include sterile pustules, pain, scaling, erythema, dryness, itching, burning, joint pain, leukocytosis, headache, fever, and fatigue

Generalized pustular psoriasis (GPP) is heterogenous and can be a relapsing disease with recurrent flares or a persistent disease with intermittent flares

GPP is phenotypically, histopathologically, and genetically distinct from plaque psoriasis

GPP is considered a neutrophilic disease, whereas plaque psoriasis is considered an autoimmune disease

The IL-36 pathway plays a key role in the pathogenesis of GPP, leading to the characteristic signs and symptoms of the disease

See our full disease profile

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