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Disease Profile
Osteochondritis dissecans
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-5 / 10 000
Age of onset
All ages
ICD-10
M93.2
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Kônig disease; König disease
Categories
Musculoskeletal Diseases
Summary
Osteochondritis dissecans is a joint condition that occurs when a piece of cartilage and the thin layer of bone beneath it, separates from the end of the bone. If the piece of cartilage and bone remain close to where they detached, they may not cause any symptoms. However, affected people may experience pain, weakness and/or decreased range of motion in the affected joint if the cartilage and bone travel into the joint space. Although osteochondritis dissecans can affect people of all ages, it is most commonly diagnosed in people between the ages of 10 and 20 years.[1][2] In most cases, the exact underlying cause is unknown. Rarely, the condition can affect more than one family member (called
Symptoms
- Pain, swelling and/or tenderness
- Joint popping
- Joint weakness
- Decreased range of motion
Although osteochondritis dissecans can develop in any joint of the body, the knee, ankle and elbow are most commonly affected. Most people only develop the condition in a single joint.[2]
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Abnormality of the knee | 0002815 | |
Arthralgia |
Joint pain
|
0002829 |
Joint stiffness |
Stiff joint
Stiff joints
[ more ] |
0001387 |
Joint swelling | 0001386 | |
30%-79% of people have these symptoms | ||
Decreased hip abduction | 0003184 | |
Limited elbow extension |
Decreased elbow extension
Elbow limited extension
Limitation of elbow extension
Limited extension at elbows
Limited forearm extension
Restricted elbow extension
[ more ] |
0001377 |
Limited elbow flexion | 0006376 | |
5%-29% of people have these symptoms | ||
Abnormality of tibia morphology |
Abnormality of the shankbone
Abnormality of the shinbone
[ more ] |
0002992 |
Gait disturbance |
Abnormal gait
Abnormal walk
Impaired gait
[ more ] |
0001288 |
Quadriceps muscle atrophy |
Wasting of quad muscles
|
0009050 |
Cause
In some families, osteochondritis dissecans is caused by changes (
Diagnosis
For more information about the diagnosis of osteochondritis dissecans, please click here.
Treatment
If non-surgical treatments are not successful or the case is particularly severe (i.e. the cartilage and bone are moving around within the joint space), surgery may be recommended. Following surgery,
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Social Networking Websites
- Visit the following Facebook groups related to Osteochondritis dissecans:
Osteochondritis Dissecans Suport Group (Adolescents)
Osteochondritis Dissecans (OCD) Support
Osteochondritis Dissecans (UK) Support
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- FamilyDoctor.org provides additional information about Osteochondritis dissecans. Click on the link above to access this information.
- KidsHealth from Nemours has an information page on Osteochondritis dissecans. Click on the link to access this resource.
- Mayo Clinic has an information page on Osteochondritis dissecans.
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases. Click on the link to view information on this topic.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Osteochondritis dissecans. Click on the link to view a sample search on this topic.
References
- Osteochondritis dissecans. Mayo Clinic. September 2012; https://www.mayoclinic.org/diseases-conditions/osteochondritis-dissecans/basics/symptoms/con-20024803.
- Osteochondritis Dissecans. American Academy of Orthopaedic Surgeons. March 2012; https://orthoinfo.aaos.org/topic.cfm?topic=A00610.
- Familial osteochondritis dissecans. Genetics Home Reference. October 2012; https://ghr.nlm.nih.gov/condition/familial-osteochondritis-dissecans.
- Grant Cooper, MD. Osteochondritis Dissecans. Medscape Reference. May 2014; https://emedicine.medscape.com/article/1253074-overview#a0112.
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